According to the provincial governor, 16 people – 12 of them civilians – lost their lives in the strike. Among the victims are four children and four women.
The latest deadly US-led drone attack occurred in the Watapur district of Kunar Province, which lies near the border with Pakistan.
It is a fighter stronghold, and many Arab and other foreign fighters are believed to operate there alongside the Afghan Taliban.
Civilian killings at the hands of US-led forces have been a source of tension between Kabul and Washington in recent years. The attacks have also increased anti-American sentiment among Afghans, who hold regular protests to condemn them.